IVF Experts
Severe Ovarian Dysfunction

When the Ovaries
Fall Silent.

Primary Ovarian Failure (Premature Ovarian Insufficiency) strikes before age 40, depleting the follicle pool and pushing women into early menopause. While devastating, it is not always absolute. Dr. Adnan Jabbar in Lahore offers comprehensive management including hormonal replacement, donor egg IVF, and pioneering stem cell ovarian rejuvenation to challenge this diagnosis.

Urgent Consultation
Primary Ovarian Failure Treatment by Dr. Adnan Jabbar

A Devastating Diagnosis

POF affects 1% of women under 40. Elevated FSH >40 IU/L with absent periods confirms the ovaries have stopped functioning prematurely.

Understanding Primary Ovarian Failure

Unlike Diminished Ovarian Reserve (where some follicles remain), POF represents a near-complete depletion. The ovaries no longer respond to even massive doses of gonadotropins, periods stop, and estrogen levels plummet — triggering menopausal symptoms decades too early.

  • Autoimmune: The immune system attacks and destroys ovarian follicles — often associated with thyroid autoimmunity, Addison's disease, or Type 1 Diabetes.
  • Genetic (Turner's, FMR1): Chromosomal abnormalities like Turner Syndrome (45,X) or Fragile X premutations cause accelerated follicle depletion.
  • Iatrogenic: Chemotherapy (especially alkylating agents), pelvic radiation, or aggressive ovarian surgery permanently destroys the follicle pool.
  • Idiopathic (~50%): In half of all cases, no cause is identified — the follicles simply deplete prematurely without explanation.

Diagnostic Confirmation

FSH >40 IU/L (x2 tests)

Two FSH readings above 40, taken at least 4 weeks apart, confirm ovarian failure with high certainty.

AMH <0.1 ng/mL

Undetectable AMH levels confirm near-complete depletion of the primordial follicle pool.

Absent Menses ≥4 Months

Amenorrhea (absent periods) in a woman under 40 is the clinical trigger for POF evaluation.

Pathways to Motherhood Despite POF

The right pathway depends on whether residual ovarian function exists, the patient's age, and her emotional readiness for different options.

Donor Egg IVF

For women with no remaining follicles, donor egg IVF offers success rates exceeding 60% per cycle. The uterus can carry a pregnancy perfectly well even when the ovaries have failed — hormonal support is provided externally.

Stem Cell Rejuvenation

Emerging stem cell and PRP protocols aim to reactivate dormant primordial follicles. Dr. Adnan Jabbar offers cutting-edge ovarian rejuvenation therapies at his Lahore clinic.

Hormonal Replacement

Even when fertility cannot be restored, HRT (estrogen + progesterone) is critical to protect heart health, bone density, and mental well-being in young women with POF.

Expert Primary Ovarian Failure Treatment in Lahore

A diagnosis of premature ovarian failure is emotionally devastating. Many young women in Pakistan are told there is simply "nothing that can be done." Dr. Adnan Jabbar rejects this verdict. His comprehensive approach includes thorough autoimmune and genetic workup, hormone replacement therapy to protect long-term health, donor egg IVF programs with exceptional success rates, and pioneering stem cell-based ovarian rejuvenation protocols. He provides compassionate, evidence-based care to women facing this challenging diagnosis across Lahore and Pakistan.

Frequently Asked Questions About Primary Ovarian Failure

Is POF the same as menopause?

Not exactly. True POF (now called Premature Ovarian Insufficiency) means the ovaries fail before age 40. Unlike natural menopause, up to 5-10% of POF patients experience spontaneous ovulation and even natural pregnancy unpredictably. This intermittent function is key — it means residual follicles may still exist.

Can I have a biological child with POF?

With donor egg IVF, success rates exceed 60% per cycle because the uterus remains fully functional. Alternatively, stem cell ovarian rejuvenation is an emerging option that aims to reactivate your own dormant follicles — a frontier Dr. Adnan Jabbar is pioneering in Pakistan.

Why is HRT important even if I don't want more children?

Without estrogen replacement, young women with POF face significantly increased risks of osteoporosis, cardiovascular disease, cognitive decline, and depression. HRT until the natural age of menopause (50-51) is strongly recommended by all major guidelines.

You are not defined by this diagnosis.

POF demands compassionate expertise. Dr. Adnan Jabbar has helped women across Pakistan navigate this challenging journey — with donor egg programs, stem cell research, and unwavering emotional support.

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