A diagnosis of Klinefelter Syndrome (47,XXY) historically meant absolute sterility. Today, with the advent of Micro-TESE surgical retrieval and world-class embryology, many men with Klinefelter’s go on to father their own biological children. Let us prove it.
Discuss Your Options PrivatelyMost men have one X and one Y chromosome (46,XY). Men with Klinefelter Syndrome are born with an extra X chromosome (47,XXY).
This extra chromosome disrupts the normal development of the testicles, leading to extremely low testosterone levels and, almost always, Non-Obstructive Azoospermia (zero sperm in the ejaculate).
While the vast majority of the testicle may be devoid of sperm, we frequently find isolated "islands" of normal, healthy sperm production hidden deep within the testicular tissue. We just have to go in and find them.
* Age is a critical factor. The earlier we perform surgical retrieval, the higher the chance of finding living sperm.
The gold standard treatment globally for Klinefelter’s fertility is Microdissection Testicular Sperm Extraction (Micro-TESE) paired with ICSI.
Using a high-powered operating microscope, Dr. Adnan Jabbar carefully opens the testicle and visually scans for slightly swollen, healthy-looking seminiferous tubules. These specific tubules are the most likely to contain the targeted "islands" of sperm.
By only removing these specific tubules, we maximize the chance of finding sperm and minimize damage to the patient's already fragile testosterone-producing tissue.
If we find even one single living sperm under the laboratory microscope, we immediately inject it into the wife's egg using ICSI, creating an embryo that is genetically yours.
With Micro-TESE, we successfully retrieve sperm in up to 50% of Klinefelter patients, radically changing the definition of sterility.