Immunomodulatory Therapy

The Healing Power of
Mesenchymal Cells.

Name: Mesenchymal Stem Cells for Fertility
Creator: Dr. Adnan Jabbar

Mesenchymal Stem Cells (MSCs) — sourced from bone marrow, Wharton's Jelly (umbilical cord), or placental tissue — possess extraordinary immunomodulatory and anti-inflammatory properties. In reproductive medicine, they repair damaged endometrium, modulate uterine immune responses, and reduce the fibrosis that blocks both implantation and spermatogenesis. Dr. Adnan Jabbar brings MSC/MHUC-based therapies to Lahore in collaboration with Sakina International Hospital and The University of Lahore.

Explore MSC Therapy

The Immune Regulators

MSCs suppress harmful immune responses while promoting tissue repair — critical for implantation failure and recurrent pregnancy loss.

Sources of Mesenchymal Stem Cells

MSCs can be harvested from multiple tissue sources, each with distinct clinical advantages.

Wharton's Jelly (Umbilical Cord)

The richest source. Wharton's Jelly MSCs are younger, more potent, and have superior immunomodulatory capacity compared to adult-derived MSCs. Non-invasive harvest from donated umbilical cords.

Bone Marrow

The original MSC source. BM-MSCs have extensive clinical data backing their safety and efficacy. Harvested via aspiration from the iliac crest under local anesthesia.

Placental Tissue

Placenta-derived MSCs share the immune-privileged nature of the fetal-maternal interface, making them uniquely suited for reproductive applications.

MSC Applications in Reproductive Medicine

Endometrial Regeneration

MSCs repair thin endometrium (<7mm) and dissolve intrauterine adhesions (Asherman's Syndrome) by secreting anti-fibrotic factors and promoting new endometrial gland formation. Critical for women with repeated implantation failure.

Recurrent Pregnancy Loss

MSCs modulate the uterine immune environment by suppressing NK cell overactivity and promoting regulatory T-cells — addressing the immune dysregulation behind unexplained recurrent miscarriage.

Ovarian Support

MSC exosomes enhance granulosa cell survival, reduce ovarian fibrosis, and support follicle development — used alongside ADSCs for comprehensive ovarian rejuvenation.

Testicular Anti-Inflammation

MSCs suppress autoimmune orchitis and reduce chronic testicular inflammation, restoring the Sertoli cell niche needed for spermatogenesis in men with inflammatory testicular failure.

Exosome-Based Therapy: Cell-Free Regeneration

The next evolution: MSC-derived exosomes deliver the therapeutic cargo (growth factors, mRNA, microRNA) without transplanting cells. Benefits include:

No cell survival concerns — exosomes work immediately
Standardized, reproducible dosing
Can be stored and shipped without complex cryopreservation
Zero tumorigenic risk since no live cells are transplanted

Clinical Partnership

MSC and exosome protocols at Dr. Adnan Jabbar's clinic are performed in collaboration with Sakina International Hospital, with research methodology validated by The University of Lahore.

FAQs About MSCs & MHUCs

What makes umbilical cord MSCs special?

Wharton's Jelly MSCs are biologically younger with higher proliferative capacity, stronger immunomodulation, and lower immunogenicity than adult-derived MSCs. They are the gold standard for allogeneic (donor) stem cell therapy.

Can MSCs help with thin endometrium?

Yes. MSC infusion into the uterine cavity or subendometrial injection has been shown to increase endometrial thickness in women with refractory thin lining, enabling successful embryo transfer in previously failed IVF cycles.

Are donor MSCs safe?

MSCs are immune-privileged — they express very low levels of MHC class II molecules, meaning they rarely trigger immune rejection. Wharton's Jelly MSCs have an extensive safety record across thousands of clinical applications worldwide.

The Healing Power of Mesenchymal Cells.