IVF Experts
Hormonal Male Infertility

Reawakening the
Hormonal Axis.

Hypogonadotropic Hypogonadism (HH) means the brain fails to send the hormonal signals needed to produce sperm. Unlike primary testicular failure, the testes themselves are healthy — they simply need the right command. As Pakistan's leading reproductive endocrinologist, Dr. Adnan Jabbar uses precision gonadotropin therapy (hCG + hMG) to restore natural sperm production — often without needing IVF at all.

Book Hormonal Assessment
Hormonal Male Infertility Treatment by Dr. Adnan Jabbar in Lahore

Reversible Condition

HH is one of the few male infertility diagnoses where natural fertility can be fully restored through medical therapy alone.

The HPG Axis: Command & Control

Normal sperm production requires a perfectly orchestrated hormonal cascade: the hypothalamus releases GnRH, which tells the pituitary to secrete LH and FSH. LH drives testosterone production; FSH drives spermatogenesis. In HH, this chain is broken at the top — the brain.

  • Congenital HH (Kallmann Syndrome): Born with absent GnRH neurons. Often presents with delayed puberty and absent sense of smell (anosmia).
  • Acquired HH: Caused by pituitary tumors (prolactinomas), anabolic steroid abuse, severe obesity, or chronic opioid use — all of which suppress LH/FSH.
  • Steroid-Induced: Exogenous testosterone and anabolic steroids shut down the natural HPG axis, often leading to complete azoospermia (zero sperm).

Diagnostic Profile

Low LH + Low FSH

The hallmark: both pituitary hormones are inappropriately low, confirming the brain is not commanding the testes.

Low Testosterone

Serum testosterone is suppressed because Leydig cells in the testes are not receiving LH stimulation.

Azoospermia or Severe Oligospermia

Semen analysis shows zero or critically low sperm counts because FSH-driven spermatogenesis has stalled.

Restoring Fertility Without IVF

HH is a uniquely treatable form of male infertility. By replacing the missing hormonal signals, Dr. Adnan Jabbar can often restore natural sperm production entirely.

Gonadotropin Therapy (hCG + hMG)

Dr. Adnan Jabbar administers injectable hCG (to replace LH) and hMG (to replace FSH) over 6-18 months. The testes gradually increase in size, testosterone levels normalize, and sperm progressively appear in the ejaculate.

Success Rate: Up to 80% of men with HH achieve sperm in the ejaculate sufficient for natural conception or IUI, avoiding IVF entirely.

Clomiphene / Anti-Estrogen Protocol

For acquired HH (especially steroid-induced), oral Clomiphene Citrate or Tamoxifen can jumpstart the pituitary by blocking estrogen feedback. This is a simpler, non-injectable first-line approach.

Ideal For: Post-steroid recovery, obesity-related HH, and mild idiopathic cases where some residual pituitary function exists.

Best Hypogonadotropic Hypogonadism Specialist in Pakistan

Hypogonadotropic Hypogonadism is frequently misdiagnosed as "low testosterone" and treated with testosterone replacement — which paradoxically destroys fertility by shutting down the remaining sperm production. Dr. Adnan Jabbar is one of Pakistan's foremost specialists in hormonal male infertility, correctly diagnosing HH and implementing fertility-preserving gonadotropin therapy. His approach has restored natural fertility in hundreds of men across Lahore and Pakistan who were previously told fatherhood was impossible.

Correct Diagnosis First

We differentiate HH from primary testicular failure using the LH/FSH ratio — because the treatment pathway is entirely different.

Fertility-First Protocol

We never use exogenous testosterone for men wanting children. Instead, we restore the natural axis with gonadotropins to produce both testosterone AND sperm simultaneously.

Post-Steroid Recovery

Pakistan has a growing epidemic of anabolic steroid abuse causing severe infertility. Dr. Adnan Jabbar specializes in reversing this specific type of acquired HH.

Frequently Asked Questions About Hypogonadotropic Hypogonadism

Answering common questions about hormonal male infertility and recovery.

Can men with Hypogonadotropic Hypogonadism father children naturally?

Yes — this is one of the most treatable causes of male infertility. With gonadotropin injections (hCG and hMG) administered over several months, up to 80% of men with HH can produce enough sperm to conceive naturally or via simple IUI, without needing IVF or ICSI.

Will testosterone injections help me produce sperm?

No — this is a critical mistake. Exogenous testosterone actually suppresses your pituitary gland further, shutting down any remaining LH and FSH production and destroying spermatogenesis. If your goal is fatherhood, you must avoid testosterone replacement and instead receive fertility-specific gonadotropin therapy from a specialist like Dr. Adnan Jabbar.

How long does gonadotropin treatment take to produce sperm?

Spermatogenesis (the full cycle of sperm production) takes approximately 72-74 days. However, the testes must first increase in volume and begin functioning. Most men see the first sperm appear within 6-12 months of gonadotropin therapy. For congenital HH (Kallmann Syndrome), it may take 12-24 months but the results are often excellent.

Your hormones can be restored.

HH is reversible. Dr. Adnan Jabbar's gonadotropin protocols have restored natural fertility in hundreds of men across Pakistan. The testes are healthy — they just need the right signal.

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