IVF Experts
Severe Male Infertility

When the Testes
Cannot Respond.

Primary Testicular Failure (Hypergonadotropic Hypogonadism) is among the most challenging forms of male infertility. The testes themselves are damaged — no amount of hormonal stimulation can create normal function. Yet, even in these severe cases, Dr. Adnan Jabbar has recovered sperm through Micro-TESE in patients who were told fatherhood was impossible.

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Primary Testicular Failure Specialist Dr. Adnan Jabbar Lahore

The Critical Distinction

High FSH + Low Testosterone = the testes have failed. Unlike HH, the brain is screaming for the testes to work, but they cannot respond.

Understanding Primary Testicular Failure

In primary testicular failure, the damage exists within the testicular tissue itself. The pituitary gland correctly senses the low testosterone and ramps up FSH and LH production to maximum levels — but the testes cannot respond. This distinguishes it completely from Hypogonadotropic Hypogonadism.

  • Sertoli Cell-Only Syndrome: The testicular tubules contain only Sertoli support cells — the germ cells needed to produce sperm are entirely absent.
  • Maturation Arrest: Sperm production begins but halts at an immature stage — spermatocytes fail to complete meiosis and never become functional sperm.
  • Post-Chemotherapy: Alkylating agents used in cancer treatment destroy the spermatogonial stem cells, often irreversibly.

Diagnostic Hallmarks

Elevated FSH (>12 IU/L)

The pituitary is overproducing FSH in a desperate attempt to stimulate failing testicular tissue — this is the hallmark of primary failure.

Small Testicular Volume (<6 mL)

Severely atrophic testes with minimal seminiferous tubule tissue remaining.

Non-Obstructive Azoospermia

No sperm in the ejaculate, not because of a blockage, but because the factories themselves have failed to produce.

Advanced Rescue Strategies

Even in severe primary failure, Dr. Adnan Jabbar deploys multiple rescue strategies that have achieved fatherhood for patients who were previously considered untreatable.

Micro-TESE

Microsurgical Testicular Sperm Extraction under 20-40x magnification identifies rare pockets of active spermatogenesis within otherwise atrophic tissue. Success rates reach 40-60% even in Sertoli Cell-Only Syndrome.

Hormonal Optimization

Pre-treating with hCG, Clomiphene, or Aromatase Inhibitors for 3-6 months before Micro-TESE can optimize the intratesticular hormonal environment and increase sperm retrieval rates.

Stem Cell Regeneration

Emerging stem cell therapies aim to regenerate damaged spermatogonial stem cells and restore spermatogenesis — a frontier Dr. Adnan Jabbar is actively pursuing.

Pakistan's Leading Expert in Severe Male Infertility

Primary Testicular Failure represents the most severe end of the male infertility spectrum. Many patients in Pakistan are incorrectly told they can never father biological children. Dr. Adnan Jabbar challenges this verdict with systematic hormonal pre-treatment, state-of-the-art Micro-TESE surgery, and cutting-edge stem cell research — recovering sperm in cases where other clinics have failed. His expertise in Non-Obstructive Azoospermia management is recognized across Lahore and Pakistan.

Frequently Asked Questions About Primary Testicular Failure

Is there any hope for fatherhood with primary testicular failure?

Yes. Even in severe cases with Sertoli Cell-Only Syndrome or maturation arrest, Micro-TESE can recover sperm in 40-60% of cases. These sperm are then used with ICSI to fertilize eggs. Dr. Adnan Jabbar has helped numerous men with primary testicular failure achieve biological fatherhood.

What is the difference between primary and secondary testicular failure?

Primary testicular failure (hypergonadotropic) means the testes themselves are damaged (high FSH). Secondary failure (hypogonadotropic) means the brain/pituitary isn't sending the right hormonal signals (low FSH). This distinction is critical because secondary failure is far more treatable with hormone therapy alone.

Can stem cells restore testicular function?

This is an active research frontier. Early clinical data from adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) injected into testicular tissue show promising results in restoring limited spermatogenesis. Dr. Adnan Jabbar is at the forefront of this research in Pakistan.

Failure is not final.

Where others see impossibility, Dr. Adnan Jabbar sees potential. His systematic approach has reclaimed fertility for men across Pakistan facing the most severe testicular conditions.

Consult Dr. Adnan Jabbar