IVF Experts
Regenerative Medicine Frontier

Regenerating
Testicular Function.

When the testes have been damaged beyond what traditional medicine can repair — whether by primary testicular failure, chemotherapy, or congenital conditions — stem cell therapies represent the next frontier. Dr. Adnan Jabbar is pioneering the use of Adipose-Derived Stem Cells (ADSCs), Mesenchymal Stem Cells (MSCs), and spermatogonial stem cell research to regenerate testicular tissue and restore spermatogenesis in Lahore, Pakistan.

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Stem Cell Testicular Recovery Research at Dr. Adnan Jabbar's Clinic

The Promise of Regeneration

Stem cells can differentiate into Sertoli cells, Leydig cells, and potentially even spermatogonia — offering hope where none existed before.

The Science of Testicular Regeneration

Stem cells possess the remarkable ability to self-renew and differentiate into specialized cell types. When applied to testicular failure, they target the fundamental cellular infrastructure needed for sperm production.

Paracrine Effect

Stem cells release powerful growth factors, cytokines, and exosomes that repair damaged testicular tissue from the inside — reducing fibrosis, increasing blood flow, and reawakening dormant spermatogonial stem cells resident within the testes.

  • VEGF — restores testicular microvasculature
  • IGF-1 — promotes Sertoli cell survival
  • Anti-inflammatory cytokines — reduce fibrosis

Cellular Replacement

In more advanced research, stem cells can potentially differentiate directly into the supportive cells needed for spermatogenesis — replacing damaged Sertoli cells and Leydig cells to restore both testosterone production and sperm development.

  • Sertoli cell regeneration — restores the "nurse cells"
  • Leydig cell renewal — normalizes testosterone
  • Germ cell differentiation — potential for new spermatogonia

Stem Cell Types Used in Testicular Recovery

Each stem cell type offers distinct advantages for testicular regeneration.

ADSCs

Adipose-Derived Stem Cells

Harvested from the patient's own fat tissue via mini-liposuction. These multipotent cells secrete powerful growth factors when injected into testicular tissue, reducing inflammation and activating dormant spermatogonia. Autologous — zero rejection risk.

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MSCs / MHUCs

Mesenchymal & Umbilical Cord

Mesenchymal Stem Cells from bone marrow or Wharton's Jelly (umbilical cord) possess strong immunomodulatory properties. They suppress the autoimmune-mediated destruction of testicular tissue seen in some forms of orchitis and reduce chronic inflammation.

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SSC Transplant

Spermatogonial Stem Cells

The ultimate frontier: isolating a patient's own spermatogonial stem cells (SSCs) before chemotherapy, preserving them, and re-transplanting them into the testes post-treatment to restore endogenous sperm production. Currently in advanced clinical trials globally.

Role in infertility →

Dr. Adnan Jabbar: Pioneering Stem Cell Fertility in Pakistan

While mainstream fertility clinics in Pakistan rely exclusively on traditional IVF and ICSI, Dr. Adnan Jabbar is actively integrating regenerative medicine into his practice. His approach combines conventional Micro-TESE with cutting-edge stem cell protocols — offering a dual strategy that maximizes the chances of sperm recovery for men with severe testicular failure. As a recognized leader in reproductive medicine across Lahore and Pakistan, he brings global research insights to local clinical practice.

Autologous ADSC Protocol

Fat-derived stem cells from the patient's own body, processed and injected into testicular tissue under ultrasound guidance.

Pre-Micro-TESE Priming

Stem cell injection 3-6 months before surgical sperm retrieval to optimize the testicular microenvironment and increase sperm yield.

Research & Innovation

Actively collaborating with international research institutions to bring the latest stem cell fertility protocols to Pakistan.

Frequently Asked Questions About Stem Cell Testicular Recovery

Is stem cell therapy for testicular failure available in Pakistan?

Dr. Adnan Jabbar is among the pioneering specialists in Pakistan offering investigational stem cell protocols for male infertility. While globally this remains an emerging field, his clinic in Lahore provides carefully designed ADSC-based protocols integrated with conventional fertility treatments.

How are stem cells harvested for testicular injection?

For autologous ADSCs, a small amount of fat tissue is collected via mini-liposuction (under local anesthesia). The stem cells are then isolated, concentrated, and injected directly into the testicular tissue. The entire process is minimally invasive and same-day.

Can stem cells create new sperm cells?

Current evidence suggests stem cells primarily regenerate the supportive environment (Sertoli and Leydig cells) needed for spermatogenesis, and can reactivate dormant spermatogonial stem cells already present in the testes. Direct generation of new germ cells from exogenous stem cells remains a research frontier.

The future of fertility is regenerative.

Dr. Adnan Jabbar is bringing cutting-edge stem cell science from global research labs to clinical practice in Lahore. If conventional treatments have failed, regenerative medicine may offer a new path.

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