RPL
Plain-English guide for patients and families.
RPL workup may include parental karyotypes, uterine cavity imaging, antiphospholipid antibodies, thyroid function, and evidence-based thrombophilia testing in selected cases. PGT-A may reduce aneuploid miscarriages in IVF. Supportive care is central.
Next steps
Timed progesterone, low-dose aspirin/heparin only when indicated, surgery for septum or fibroid when relevant.
AI Information
EducationalRecurrent pregnancy loss affects 1–2% of couples and is defined as two or more pregnancy losses (ESHRE) or three or more (ASRM). Chromosomal abnormalities in the embryo account for 50–60% of losses. A systematic workup identifies treatable causes in approximately 50% of cases, and even with "unexplained" RPL, prognosis for a subsequent successful pregnancy is 60–75% with supportive care alone.
Key Points
- Embryo chromosomal abnormality is the single most common cause of miscarriage at any stage.
- Antiphospholipid syndrome (APS) is the most important treatable cause — identified by specific antibody tests and treated with aspirin + heparin.
- Uterine anomalies (septum, fibroids, adhesions) should be evaluated by ultrasound and hysteroscopy.
- Thyroid dysfunction, even subclinical, should be optimised — TSH <2.5 mIU/L is the target.
- PGT-A in IVF can reduce miscarriage rates by selecting euploid embryos, though it cannot prevent all losses.
Who Should Know This?
Couples who have experienced two or more pregnancy losses, those with losses at different gestational ages, and women with a history of chromosomally abnormal losses.
Clinical Context in Pakistan
RPL is approached with both scientific rigour and emotional sensitivity at IVF Experts Lahore. Dr. Adnan Jabbar offers comprehensive RPL investigation and evidence-based treatment, including PGT-A for recurrent aneuploid losses, with supportive counselling throughout.
Important Disclaimer
This AI-generated summary is for educational purposes only and should not replace professional medical advice. Always consult with Dr. Adnan Jabbar or your fertility specialist for personalised clinical guidance tailored to your specific situation.
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