Preimplantation Genetic Testing (PGT)

Embryo biopsy for chromosome or single-gene conditions before transfer.

Ask Dr. Adnan All Terms

Medically reviewed by Dr. Adnan Jabbar

· Updated April 2026

PGT

Plain-English guide for patients and families.

PGT refers to lab tests on cells from embryos created through IVF. PGT-A screens chromosome numbers; PGT-M targets known single-gene disorders; PGT-SR looks at structural rearrangements. It helps select embryos for transfer and can reduce some miscarriage risks in selected groups — not every patient needs it.

Who may be offered PGT

Older maternal age, recurrent pregnancy loss, repeated implantation failure, severe male factor with DNA damage concerns, or known genetic carrier status. Ethical and legal frameworks vary; your clinic counsels you on indications and limitations.

AI Information

Educational

PGT allows embryos to be screened for genetic abnormalities before transfer, representing a major advance in IVF technology. PGT-A (aneuploidy screening) can identify embryos with the correct chromosome number, potentially reducing miscarriage rates and time to pregnancy in selected patient groups. PGT-M prevents transmission of known single-gene disorders like thalassemia, cystic fibrosis, and sickle cell disease.

Key Points

PGT-A screens for chromosome number abnormalities (aneuploidy) — the most common cause of failed implantation and early miscarriage.
PGT-M can test for over 600 single-gene disorders when family carrier status is known.
Biopsy is performed at the blastocyst stage (day 5–6) from the trophectoderm, which becomes the placenta.
Results take 1–2 weeks; embryos are frozen during testing and transferred in a subsequent cycle.
PGT does not guarantee pregnancy — it improves selection but cannot overcome all factors.

Who Should Know This?

Women over 37 undergoing IVF, couples with recurrent pregnancy loss, those with repeated implantation failure, known carriers of genetic conditions, and couples with a family history of chromosomal abnormalities.

Clinical Context in Pakistan

PGT is particularly relevant in Pakistan where consanguineous marriages increase the risk of autosomal recessive conditions. Dr. Adnan Jabbar offers genetic counselling and PGT coordination for at-risk couples at IVF Experts Lahore.

Important Disclaimer

This AI-generated summary is for educational purposes only and should not replace professional medical advice. Always consult with Dr. Adnan Jabbar or your fertility specialist for personalised clinical guidance tailored to your specific situation.