RIF
Plain-English guide for patients and families.
Hope
Many couples eventually succeed after adjusting protocol, surrogacy, or donor gametes depending on findings.
AI Information
EducationalRecurrent implantation failure is one of the most frustrating scenarios in IVF — good embryos transferred to a seemingly normal uterus that fail to implant. While there is no universally agreed definition, most specialists consider RIF after 2–3 failed transfers of good-quality embryos. A systematic, multi-factorial investigation is key to identifying treatable causes.
Key Points
- RIF is typically defined as failure to achieve clinical pregnancy after transfer of ≥4 good-quality embryos in ≥3 fresh/frozen cycles.
- Embryo factor (undetected aneuploidy) remains the most common explanation — PGT-A can address this.
- Endometrial factors include chronic endometritis (treatable with antibiotics), polyps, and displaced implantation window.
- Sperm DNA fragmentation may contribute to failed implantation even when embryo morphology appears normal.
- Immune testing and treatment for RIF remain controversial — evidence is evolving and should be approached cautiously.
Who Should Know This?
Couples who have had multiple failed IVF transfers despite apparently good embryos, those who have not yet tried PGT-A, and patients with unexplained IVF failures.
Clinical Context in Pakistan
Dr. Adnan Jabbar offers a structured RIF evaluation protocol at IVF Experts Lahore, systematically addressing embryo, endometrial, sperm, and systemic factors before the next transfer attempt.
Important Disclaimer
This AI-generated summary is for educational purposes only and should not replace professional medical advice. Always consult with Dr. Adnan Jabbar or your fertility specialist for personalised clinical guidance tailored to your specific situation.
Related Glossary Terms
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